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The story
The Japan Society for the Study of Obesity announced on October 3 that the diabetes drug “Mounjaro” should not be used for rapid weight loss or extreme dietary restriction. The statement warns against the drug’s growing use for dieting purposes, citing risks of health problems such as vomiting and abdominal pain, and will be published on the society’s website on the 5th. In response to this report, reactions on 5ch centered on explanations of how Mounjaro actually works — that it isn’t insulin itself but a drug that promotes insulin secretion — along with firsthand accounts from people actually using it or being prescribed it, covering the price gap between insured and cosmetic use, and how easily people rebound after stopping.
Oct 3 (Sat), 20:17
Yomiuri Shimbun Online
The Japan Society for the Study of Obesity announced on the 3rd a statement saying that diabetes drugs such as Mounjaro should not be used for rapid weight loss or excessive dietary restriction. The statement responds to the spreading use of the drug for dieting purposes, warning that such use carries risks of health problems including vomiting and abdominal pain. It will be published on the society’s website on the 5th.
Source: news.yahoo.co.jp / Original article here
What people said
Telling someone who can't help stress-eating to just stop eating is like forcing an impossible task on a sick person. If your numbers are bad and you're covered by insurance for Mounjaro and the side effects aren't brutal, that's the better option.
quit Mounjaro,
you start
ballooning right back up.
Seriously?
That's pretty much how most medications go, though.
Sales guys have bellies like they swallowed a balance ball — probably from all the wining and dining with clients.
There are doctors like that too.
Which basically means
no matter how much you use Mounjaro,
you're guaranteed to rebound eventually.
Proper weight loss takes athlete-level discipline,
and almost nobody can actually manage that.
> Post 28, Anonymous Donburako (a default 5ch poster name), 2026/10/03 (Sat) 22:24:35.16 ID:JwceirkE0
> How much does Mounjaro even cost a month?
For 4 weeks (1 month) without insurance (cosmetic use), four pens of the weak 2.5mg dose run just under ¥10,000.
That's a bit over ¥2,000 a pen.
Most people find that dose underwhelming, but
the YouTuber from "Sanocchi TV" had it hit so hard he got sick and had to quit.
Said food sat in his stomach for days and he couldn't stop burping.
Normally people bump the dose up when 2.5mg feels too weak, but how it hits you varies a lot person to person.
With insurance for diabetes, it gets cheaper.
I use it legally, and the effect is absolutely real.
The results and the feeling of it are both unmistakable.
If the effect is that insane, the side effects are definitely nasty too.
isn't it only obtainable through shady channels?
It's long since become available through regular insured prescriptions.
As of this August, the drug price was revised and it got cheaper.
Why not just officially approve this one as a diet drug?
Hair-growth drugs are heart medication too — except repurposed that way they don't work, and they'll kill you lol
apparently I'm at risk of diabetes.
That's not a "risk" — you're already solidly diabetic at that point.
but if you were able to exercise, you wouldn't be this fat to begin with.
Just not leaning on cars, elevators, and escalators for every little trip counts as exercise.
Seriously?
Taking a break cuts down on overeating?
> Post 91, Anonymous Donburako, sage (posted without bumping the thread), 2026/10/03 (Sat) 23:15:10.53 ID:JygRLkXr0
> I'm on Mounjaro treatment, but my appetite isn't dropping at all??
Healthy life expectancy is limited, so humble yourself and beg your doctor to up the dose.
If your secretion's already normal despite being fat, wouldn't it just strain your pancreas, and you'd end up diabetic anyway even after losing the weight? How does that work?
I'm actually a type 2 diabetic prescribed Mounjaro by a specialist, so let me explain what I know.
Mounjaro, the diabetes drug → is NOT an insulin injection.
Mounjaro is a GIP/GLP-1 receptor agonist,
and works the same way as the hormones (GIP and GLP-1) that promote insulin secretion.
When blood sugar rises, GIP/GLP-1 get released from the small intestine,
and once they reach the pancreas, they signal it to release insulin.
Diabetics inject insulin to lower their blood sugar,
but Mounjaro gets injected to make the pancreas secrete insulin instead.
Either way, both insulin and Mounjaro are injections aimed at lowering blood sugar.
Apparently it gives insulin secretion more of a rhythm, so the pancreas actually gets to rest properly when it should — which is supposed to be a good thing. But that's strictly for type 2 diabetics whose insulin output is already sufficient.
Re: #121
That's exactly why they didn't give Mounjaro an obesity indication and instead released a separate obesity-targeted version under the name "Zepbound." Letting just anyone use it to lose weight would probably be a problem, but they clearly do want in on obesity treatment.
this is the first genuine "weight loss drug" humanity has ever gotten its hands on,
so plenty of people are going to want it no matter what.
All it does is dull your appetite somewhat, so calling it a weight-loss drug is a stretch.
It's fundamentally a treatment for diabetics that makes the pancreas secrete insulin to lower blood sugar.
Diabetics using it for anything other than treating their diabetes is simply using it wrong.
Uh, if your appetite drops, you lose weight. That's literally how it works.
it's cheaper than going to the gym.
I don't get why people go to the gym to diet —
running outside is free.
The gym is where you go to build muscle.
This drug is a drug that wipes your muscle out.
Background and Key Points of This Topic
Mounjaro (tirzepatide) is a type 2 diabetes drug that stimulates both the GIP and GLP-1 receptors to promote insulin secretion — as the thread’s more technical replies point out, it is not an insulin injection itself. Because its appetite-suppressing effect is strong, off-label “cosmetic purpose” prescriptions have spread, a trend that became easier to access following this August’s drug price revision. Overseas, it’s approved for obesity under the name “Zepbound,” but in Japan it remains positioned primarily as a diabetes treatment, with no standalone approval for obesity itself. The thread split over whether appetite loss and the resulting weight loss should be seen as “the drug working” versus “just not eating,” and opinions further diverged over how to weigh rebound risk after stopping against muscle loss and other side effects. This article keeps the technical explanations of how the drug promotes insulin secretion rather than being insulin itself, along with firsthand accounts of pricing and insurance realities, while cutting out personal attacks and off-topic jokes.
*This article is excerpted and summarized from the 5ch (News Flash+) thread “[💉] Diabetes drug Mounjaro: “Should not be used for rapid weight loss or extreme dietary restriction”… Japan Obesity Society issues statement.”
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